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KMID : 0357119930150020235
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Korean Journal of Immunology
1993 Volume.15 No. 2 p.235 ~ p.241
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Effects of Ascorbate on the Immune Responses to Tumor Cell
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Kang Young-Jun
Jeong Ga-Jin
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Abstract
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Ascorbate is well-known as the anticancer molecule and has been studied as the anticancer drug, but its action mechanism is not well understood. We examined the anticancer effects and mechanism of ascorbate on EL-4 lymphoma-implanted mice. Intraperitoneal administration of ascorbate expanded the survival of EL-4-bearing mice compared with control group(p<0.05). In vitro treatment of ascorbate did not affect the physiology of tumor cells, but in vivo treatment of ascorbate did on the immune function. Injection of ascorbate into EL-4-implanted mice enhanced the cell-mediated cytotoxicity of NK ceIls(p<0.05), without any significant effect on CTL activity. However, in vitro treatment of ascorbate did not enhance the cytotoxic activity of enriched NK cells. So, it is thought that anticancer effect of ascorbate due to the enhancement of ascorbate may be mediated by the othar mechanisms.
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KEYWORD
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Ascorbate, EL-4, Cell-mediated cytotoxicity
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